Multidimensional map of healthy and diseased children's kidneys
Research Project 1: A Multidimensional Molecular Atlas of Healthy and Diseased Human Pediatric Kidney
Creating a detailed map of the cells and gene activity in healthy and injured children's kidneys to guide better care for kids with kidney problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11172476 on NIH RePORTER |
What this research studies
This project will collect pediatric kidney tissue and clinical samples from donor organs and collaborating hospitals to represent healthy development and common childhood kidney injuries. Scientists will use single-nucleus RNA sequencing (snRNA-seq) and ATAC-seq to identify which genes are active in each cell type and how gene activity is regulated. The team will compare normal postnatal kidney development with conditions such as congenital anomalies and acute kidney injury to pinpoint molecular changes linked to disease. The shared pediatric kidney atlas and dataset will be made available to researchers to help drive new diagnostics and therapies.
Who could benefit from this research
Good fit: Ideal participants are infants, children, and young people with kidney conditions or acute kidney injury, and families willing to donate pediatric kidney tissue or allow clinical sample collection for research.
Not a fit: People without kidney problems or those seeking immediate clinical treatment are unlikely to receive direct personal medical benefit from this mapping project.
Why it matters
Potential benefit: If successful, the atlas could enable earlier diagnosis, more precise treatments, and better prevention of long-term kidney disease in children.
How similar studies have performed: Related single-cell and ATAC-seq atlases have improved understanding of adult and fetal kidneys, but a focused postnatal pediatric kidney atlas is relatively new and fills an important gap.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Jain, Sanjay — Washington University
- Study coordinator: Jain, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.