MSK center for how tumors change over time
The MSK Genomic Data Analysis Center for Tumor Evolution
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11174454
Creating tools that use patient tumor DNA and RNA to track how cancer changes during treatment and across the body.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11174454 on ClinicalTrials.gov |
What this research studies
This project will build software, workflows, and best practices to analyze tumor genomes and transcriptomes collected over time. It will combine clinical sequencing data from patients and public datasets to map how cancer cell populations evolve and develop resistance. The team will create analysis tools and infrastructure that clinicians and researchers can use to follow patients' clinical trajectories. The focus is on understanding tumor evolution across metastatic sites and during therapy.
Who could benefit from this research
Good fit: People with cancer who have had, or are willing to provide, tumor or blood samples for DNA/RNA sequencing over time—especially those with metastatic or treatment-resistant disease—are the best fit.
Not a fit: Patients without any tumor sequencing data or with cancer types not represented in the analyzed datasets are unlikely to see direct benefits from this work.
Why it matters
Potential benefit: If successful, this could help clinicians spot emerging resistant tumor clones sooner and guide more effective, personalized treatment strategies.
How similar studies have performed: Large sequencing efforts like TCGA have revealed key cancer mutations and informed therapies, but comprehensive longitudinal analyses of tumor evolution are still emerging.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHULTZ, NIKOLAUS — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SCHULTZ, NIKOLAUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.