MSK center for how the immune system fights cancer
The Center for Tumor-Immune Systems Biology at MSKCC
Researchers are combining lab work and computer modeling to help immune therapies work better for people with solid tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11176061 on NIH RePORTER |
What this research studies
This center brings together lab scientists and computational teams to understand why some cancers do not respond to immune checkpoint therapy. They use patient tumor samples, high-resolution imaging, spatial transcriptomics, single-cell analyses, and mouse models alongside machine learning to map tumor immune environments. The work focuses on tumors that resist or only partially respond to current immunotherapies to identify new targets and combination strategies. Findings from these integrated approaches are intended to point toward tests or treatments that could be tried in patients.
Who could benefit from this research
Good fit: Ideal candidates are people with solid tumors who are receiving or being considered for immune checkpoint therapy and who can provide tumor samples or join follow-up clinical studies.
Not a fit: Patients without solid tumors (for example, many blood cancers), those not eligible for immunotherapy, or those unwilling to provide tumor tissue are unlikely to benefit directly from this center's work.
Why it matters
Potential benefit: If successful, this work could lead to tests or new therapy combinations that help more people get lasting responses to cancer immunotherapies.
How similar studies have performed: Immune checkpoint therapies have produced durable remissions for some patients and recent single-cell and spatial studies have been promising, but integrating these methods into broadly effective new treatments remains an emerging area.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Leslie, Christina S — Sloan-Kettering Inst Can Research
- Study coordinator: Leslie, Christina S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.