MRI methods tuned to better detect aggressive prostate cancer in African American men
Racially-associated MRI analysis and modeling for predicting aggressive prostate cancer
Using MRI with race-specific imaging measures to improve spotting aggressive prostate cancer in African American men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11171648 on NIH RePORTER |
What this research studies
From your perspective, doctors will compare prostate MRI scans from African American and other men to see how tumors look different on standard readings and detailed perfusion measures (like Ktrans). They will use a portable calibration device (P4) to make perfusion measurements more consistent across different MRI machines and sites. The team will combine calibrated MRI values with modified interpretation thresholds and predictive models to better identify tumors that are likely to be aggressive. If you take part, your MRI and clinical data could help improve detection methods that may benefit men in your community.
Who could benefit from this research
Good fit: Ideal candidates are men undergoing prostate MRI or evaluation for suspected or known prostate cancer, especially African American men.
Not a fit: Men without prostate concerns or those not having mpMRI scans are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: Could make MRI-based detection of aggressive prostate cancer more accurate for African American men, reducing missed or delayed diagnoses.
How similar studies have performed: Standard prostate MRI and PI-RADS help detect many cancers, and preliminary data suggest race-specific perfusion thresholds can improve detection for African American men, but the combined calibrated approach is relatively new.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sung, Kyung Hyun — University of California Los Angeles
- Study coordinator: Sung, Kyung Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.