MRI method to detect bleeding kidney cysts and predict risk in ADPKD
QSM for detection of hemorrhaging cysts and risk stratification in ADPKD
This project uses a special MRI technique (quantitative susceptibility mapping, QSM) to find and measure bleeding cysts in adults with autosomal dominant polycystic kidney disease to help predict future kidney function loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11261226 on NIH RePORTER |
What this research studies
You would be offered advanced MRI scans that use quantitative susceptibility mapping (QSM) to look for bleeding inside kidney cysts. The team will develop and refine imaging methods and computer analysis to reliably detect and quantify hemorrhagic cysts. They will compare imaging findings with patients' kidney function and clinical data over time to see if bleeding cysts predict faster decline. The work is centered at Weill Cornell and involves people with ADPKD undergoing MRI and follow-up.
Who could benefit from this research
Good fit: Adults diagnosed with autosomal dominant polycystic kidney disease who can undergo MRI and are willing to share clinical follow-up data would be the ideal candidates.
Not a fit: People without ADPKD, those already on dialysis or with very advanced kidney failure, or individuals who cannot have MRI scans are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this could help identify ADPKD patients at higher risk of rapid kidney decline and guide treatment choices such as who may benefit most from tolvaptan.
How similar studies have performed: Previous research has linked hemorrhagic cysts to faster ADPKD progression, but applying renal QSM to detect and quantify these cysts is a newer and still-developing approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Dimov, Alexey — Weill Medical Coll of Cornell Univ
- Study coordinator: Dimov, Alexey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.