MRI mapping of severe bronchopulmonary dysplasia to predict child health outcomes
MRI Phenotyping of Severe BPD and Prediction of Outcomes
This project uses free-breathing MRI scans in infants and young children with severe bronchopulmonary dysplasia to find lung imaging patterns that predict future breathing and heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11222882 on NIH RePORTER |
What this research studies
If your child joins, they would receive free-breathing MRI scans that do not require breath-holding and are designed to work even in very sick infants. Researchers will link those MRI image patterns to existing health data from a large group of children they already follow to see which patterns line up with later breathing, asthma, or cardiac problems. The team has already developed these MRI methods, translated them into clinical use, and follows a cohort of over 250 children (most with severe disease). Over time the study will refine imaging “phenotypes” that could guide follow-up and treatments as these children grow.
Who could benefit from this research
Good fit: Ideal candidates are extremely premature infants and young children with severe bronchopulmonary dysplasia, including those who require respiratory support and are able to attend follow-up visits.
Not a fit: Children without BPD, with only mild BPD, or those who cannot undergo MRI (for example due to incompatible medical devices) are unlikely to gain direct benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could help doctors identify infants at highest risk for long-term lung and heart problems so they can get closer monitoring or earlier treatments.
How similar studies have performed: Prior work from this team and other groups has shown promising links between neonatal MRI features and short-to-medium term outcomes, and this renewal builds on that emerging evidence.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Woods, Jason C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Woods, Jason C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.