MRI-guided treatment for bleeding in the heart after a heart attack
Developing a Cardiac MRI Guided Therapy for Hemorrhagic Myocardial Infarction
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11318924
Using cardiac MRI to guide a therapy for people who have bleeding inside the heart after a heart attack to help prevent long-term heart damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11318924 on ClinicalTrials.gov |
What this research studies
This project uses advanced cardiac MRI scans to find and map bleeding (intramyocardial hemorrhage) and tiny vessel injury after a heart attack. Researchers plan to use those MRI findings to direct targeted treatments to the damaged areas following reperfusion. The work combines imaging-based classification, laboratory and animal studies, and human imaging data to design MRI-centered treatment strategies. The goal is to move from recognizing severe injury patterns to delivering therapies aimed specifically at the hemorrhagic regions.
Who could benefit from this research
Good fit: People who recently had a reperfused acute myocardial infarction and show signs of microvascular obstruction or intramyocardial hemorrhage on cardiac MRI.
Not a fit: Patients whose heart attacks did not involve microvascular obstruction or hemorrhage, or those unable to undergo cardiac MRI or interventional procedures, are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, this approach could reduce the risk of chronic heart failure and major cardiac events in heart attack survivors by limiting damage from reperfusion-related bleeding.
How similar studies have performed: Cardiac MRI has reliably shown that microvascular obstruction and hemorrhage predict worse outcomes, but MRI-guided therapies targeting hemorrhagic MI are largely new and not yet proven in humans.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DHARMAKUMAR, ROHAN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: DHARMAKUMAR, ROHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.