Mouse Models Core: Advanced mouse and human tumor models for pancreatic cancer research
Official title: Core 3: Mouse Models Core (MM Core)
Funded at Salk Institute for Biological Studies · NIH-11364249 · Data updated 2026-11-12
A dedicated core provides standardized mouse and human tumor models to support preclinical pancreatic cancer studies across multiple projects.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | July 6, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $548,418 |
| NIH project number | 5P01CA265762-04 |
| Project ID | NIH-11364249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with pancreatic cancer whose tissue or organoids may be used to create models for research through collaboration with the coordinating institutions.
✕Less likely to help
Patients whose samples are not available or whose condition does not contribute to the organoid/tumor model studies may not directly benefit.
What this research studies
If you have pancreatic cancer or are at risk, this core helps researchers test new treatments in mice and organoids using consistent methods so results are reliable. It focuses on orthotopic transplantation of mouse and human material and analyzes how different therapies and tumor environments affect growth and resistance. By standardizing imaging and procedures, it aims to make results across projects comparable and more meaningful for future patient therapies.
Why it matters
Potential benefit: If successful, this core could speed the development of effective pancreatic cancer treatments and better understand mechanisms of resistance.
How similar studies have gone: Prior preclinical mouse model cores have improved reproducibility and accelerated testing of combination therapies in cancer.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Engle, Dannielle — Salk Institute for Biological Studies
- Study coordinator: Engle, Dannielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.