Mouse model to better understand NUT carcinoma
Developing a clinically-relevant genetically engineered mouse model for Nut carcinoma
This project makes a new mouse version of NUT carcinoma so researchers can learn how the cancer starts and test safer treatments for people with NUT carcinoma.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11241125 on NIH RePORTER |
What this research studies
Researchers will build genetically engineered mice that carry the BRD4–NUTM1 fusion found in human NUT carcinoma. They will study which cell types allow the fusion protein to survive and drive tumors, since the fusion is usually toxic in other cells. The team will use the model to study tumor development and to try targeting the NUTM1 portion of the fusion as a way to avoid side effects seen with BRD4-directed drugs. Findings will guide future drug testing and help identify which patients might respond to new, less toxic approaches.
Who could benefit from this research
Good fit: Patients with NUT carcinoma, especially those whose tumors contain NUTM1 fusion genes, would be most likely to benefit from therapies developed from this work.
Not a fit: People with other types of cancer that do not involve NUTM1 fusions are unlikely to benefit directly from this mouse-focused research.
Why it matters
Potential benefit: If successful, this work could speed development of better-targeted, less toxic treatments for people with NUT carcinoma.
How similar studies have performed: Laboratory and clinical research has shown BRD4–NUTM1 drives NUT carcinoma, but drugs against BRD4 have caused intolerable side effects and targeting NUTM1 is promising yet relatively untested in patients.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Gu, Bin — Michigan State University
- Study coordinator: Gu, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.