Mouse and tissue testing center to improve lung transplant outcomes
Core C: Mouse and Cell Phenotyping Core
['FUNDING_P01'] · NORTHWESTERN UNIVERSITY · NIH-11193893
This project uses mouse lung transplants and detailed tissue tests to find what causes early and long-term transplant problems so future patients have better results.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11193893 on ClinicalTrials.gov |
What this research studies
If you are a lung transplant patient, researchers will create reliable mouse lung transplant models and use live cell imaging to watch immune cells enter the graft. They will also analyze human transplant tissues with advanced tools like CITE-seq and other single-cell and protein-level methods to profile cells and molecules. The core will provide these data and technologies to the project teams and the wider research community to make results reproducible. Together these approaches aim to pinpoint the molecular pathways behind primary graft dysfunction and chronic lung allograft dysfunction.
Who could benefit from this research
Good fit: People who have had or will have a lung transplant and who can provide tissue samples or attend follow-up visits at the transplant center are the most relevant candidates.
Not a fit: People without a lung transplant or who cannot provide tissue samples or travel to participating centers are unlikely to benefit directly from this work.
Why it matters
Potential benefit: Could reveal molecular pathways and validated targets that lead to better tests or treatments to prevent early graft failure and long-term transplant rejection.
How similar studies have performed: Similar mouse transplant models and single-cell tissue analyses have informed other transplant research, but combining live imaging with advanced human tissue phenotyping for lung transplant dysfunction is relatively new.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIDGE, KAREN M — NORTHWESTERN UNIVERSITY
- Study coordinator: RIDGE, KAREN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.