MorPhiC hub showing how human genes change cell behavior
MorPhiC Data Resource and Administrative Coordinating Center
['FUNDING_OTHER'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11419099
This project builds a public resource that maps what happens when each human gene is turned off in human cell models relevant to disease, to help researchers and ultimately patients understand gene function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11419099 on ClinicalTrials.gov |
What this research studies
You would be affected indirectly: the project will create a searchable catalog of cellular changes that occur when individual human genes are knocked out in lab-grown human cells that mimic different tissues and disease states. A coordinating center at the University of Miami will collect, standardize, analyze, annotate, and share the data so researchers can use it easily. The center will work closely with labs that produce the knockout data and with analysis teams to ensure data are FAIR (findable, accessible, interoperable, reusable). Over time the catalog aims to link genes to cellular effects that matter for diagnosis, biomarkers, and new therapies.
Who could benefit from this research
Good fit: There is no patient enrollment for this coordinating/data resource role; the work uses human cell models and shared datasets rather than recruiting patients.
Not a fit: Patients seeking immediate treatments or direct clinical care are unlikely to benefit directly from this project in the short term because it is a research data infrastructure effort.
Why it matters
Potential benefit: If successful, this resource could speed discovery of disease-causing genes, suggest new drug targets, and help researchers design better diagnostics and treatments.
How similar studies have performed: Related CRISPR and functional genomics projects have produced useful gene-by-gene data, but a large, systematic, tissue- and disease-relevant catalog across all human genes is more comprehensive and largely novel.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHURER, STEPHAN C — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: SCHURER, STEPHAN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.