Monitoring the safety of HIV medications during pregnancy and their effects on children
Surveillance Monitoring for ART Toxicities (SMARTT) Study
The SMARTT study is looking at how safe HIV medications are for pregnant women and how these medicines might affect their babies, so we can help make sure both moms and kids stay healthy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897164 on NIH RePORTER |
What this research studies
The SMARTT study investigates the safety of antiretroviral (ARV) medications taken by pregnant women with HIV and their potential effects on children born to these mothers. Using a unique surveillance approach, the study identifies adverse events related to prenatal ARV exposure by conducting regular clinical and laboratory evaluations of children. If certain health thresholds are met, additional assessments are performed to further evaluate any potential health issues. This research aims to inform guidelines for safe ARV use during pregnancy, ensuring better health outcomes for both mothers and their children.
Who could benefit from this research
Good fit: Ideal candidates for this research include children born to mothers with HIV who were exposed to antiretroviral medications during pregnancy.
Not a fit: Patients who are not born to mothers with HIV or who were not exposed to antiretroviral medications during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety guidelines for the use of HIV medications during pregnancy, ultimately protecting the health of both mothers and their children.
How similar studies have performed: Previous research has successfully informed guidelines regarding the use of antiretroviral medications during pregnancy, indicating that this approach has a foundation of success.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Williams, Paige L — Harvard School of Public Health
- Study coordinator: Williams, Paige L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.