Monitoring sugar modifications in protein production
Official title: A new approach to monitoring glycosylation during glycoprotein production
Funded at Lectenz Bio, INC. · NIH-10930160 · Data updated 2026-11-12
This study is testing a new method called GlycoSenseTM to make it easier and faster to check the sugar structures on therapeutic proteins, which helps ensure these treatments are safe and effective for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lectenz Bio, INC. NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $984,227 |
| NIH project number | 5R44GM153145-02 |
| Project ID | NIH-10930160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include patients receiving biologic therapies that rely on glycoproteins, such as those with certain cancers or autoimmune diseases.
✕Less likely to help
Patients who are not receiving biologic therapies or those with conditions unrelated to glycoprotein treatments may not benefit from this research.
What this research studies
This research focuses on improving the monitoring of glycosylation, a crucial process in the production of therapeutic proteins. By developing a new method called GlycoSenseTM, the team aims to simplify the analysis of glycan structures during production, which is essential for ensuring the safety and effectiveness of these biologics. The approach seeks to provide real-time monitoring, reducing the reliance on complex and time-consuming laboratory techniques. This could lead to more consistent and reliable production of therapeutic proteins.
Why it matters
Potential benefit: If successful, this research could enhance the quality and safety of therapeutic proteins, leading to better patient outcomes.
How similar studies have gone: While the approach is innovative, similar research has shown promise in improving the monitoring of biologic production processes.
Where this research is happening
-
Lectenz Bio, INC.
Athens, United States Active
Researchers
- Principal investigator: Yang, Loretta — Lectenz Bio, INC.
- Study coordinator: Yang, Loretta
Related research
Other NIH-funded projects on the same topics.
-
Innovative glycan-based tools to find cancer biomarkers
A new project will create highly specific sugar-targeting reagents to help detect cancer biomarkers more accurately.
-
Creating new tools to detect specific sugars in biological samples
This study is working on creating special tools that can better find and analyze certain sugars in the body that are important for understanding diseases, helping scientists and doctors improve how they diagnose and study health conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.