Monitoring immune responses during pregnancy to prevent early births
Official title: Prenatal Immunomonitoring in Spontaneous Preterm Birth Prevention (PROMIS)
Funded at Ohio State University · NIH-11063212 · Data updated 2026-11-12
This study is looking at a new way to check how a pregnant woman's immune system is working to help predict and prevent early births, so that moms and their babies can have better health outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $477,077 |
| NIH project number | 5R01HD110503-02 |
| Project ID | NIH-11063212 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are expectant mothers, particularly those with a history of preterm births or other risk factors for spontaneous preterm birth.
✕Less likely to help
Patients who are not pregnant or those with no history of preterm birth are unlikely to benefit from this research.
What this research studies
This research investigates a new method for monitoring immune responses in expectant mothers to predict and prevent spontaneous preterm births (sPTBs). By analyzing inflammatory markers and immune function, the study aims to identify women at risk for sPTB and provide targeted interventions. The approach includes collecting blood samples and assessing individual immune responses to better understand the factors leading to premature births. This innovative method seeks to improve prenatal care and outcomes for mothers and their babies.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of preterm births and improve health outcomes for both mothers and infants.
How similar studies have gone: Previous research has shown promise in using immunomonitoring techniques to predict pregnancy outcomes, suggesting that this approach may lead to significant advancements in prenatal care.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gillespie, Shannon L. — Ohio State University
- Study coordinator: Gillespie, Shannon L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.