Monitoring how drugs move across barriers in the body
In-Vivo Monitoring of Therapeutic Drug Transport Across Biological Barriers
This study is looking at how well certain medications can reach tough areas in the body, like the brain and prostate, to help make treatments safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10900584 on NIH RePORTER |
What this research studies
This research investigates how therapeutic drugs can effectively penetrate biological barriers, such as those in the brain and prostate, which often limit their effectiveness. By using advanced electrochemical sensors, the study aims to continuously monitor the transport of specific antibiotics from the bloodstream to these organs. The goal is to establish a standard for measuring how well different drugs can cross these barriers, which is crucial for developing safer and more effective treatments. Patients may benefit from improved drug therapies that minimize side effects while maximizing effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients requiring antibiotic treatment for infections that affect the brain, prostate, or liver.
Not a fit: Patients with conditions that do not involve the need for drug transport across biological barriers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug therapies with fewer side effects for patients with conditions requiring treatment across biological barriers.
How similar studies have performed: Other research has shown promise in using similar monitoring techniques to improve drug delivery across biological barriers, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Arroyo Curras, Netzahualcoyotl — Johns Hopkins University
- Study coordinator: Arroyo Curras, Netzahualcoyotl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.