Monitoring cell metabolism in bioreactors for natural product production
Optical Redox Probe for Continuous Metabolic Monitoring during Natural Products Bioprocessing
This study is working on a new tool that helps scientists keep an eye on how tiny living organisms are doing in special tanks where they make natural medicines, so they can make the process faster and easier without having to take samples all the time.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Physical Sciences, INC NIH-funded |
| Lab location | 1 site (Andover, United States) |
| Project ID | NIH-10687154 on NIH RePORTER |
What this research studies
This research focuses on developing a new optical probe that can continuously monitor the metabolic state of microorganisms in bioreactors used for producing natural products. By utilizing a two-photon excitation fluorescence sensor, the project aims to provide real-time data on cellular metabolism, which is crucial for optimizing the production processes of various medicines derived from natural sources. This innovative approach seeks to eliminate the need for time-consuming sample analysis, allowing for more efficient biomanufacturing. The collaboration between Physical Sciences Inc., the University of Massachusetts Lowell, and Northeastern University enhances the project's potential for success.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals involved in the biopharmaceutical industry or those interested in the production of natural medicines.
Not a fit: Patients not involved in biopharmaceutical production or those seeking treatments unrelated to natural product medicines may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and cost-effective production of essential medicines derived from natural products.
How similar studies have performed: Other research has shown promise in using real-time monitoring techniques in bioprocessing, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
Andover, United States
- Physical Sciences, INC — Andover, United States (Active)
Researchers
- Principal investigator: Zhao, Youbo — Physical Sciences, INC
- Study coordinator: Zhao, Youbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.