Monitoring blood flow in the brain after a stroke caused by an aneurysm.
Official title: Noninvasive monitoring of cerebrovascular regulation in subarachnoid hemorrhage.
Funded at University of South Florida · NIH-11000302 · Data updated 2026-11-12
This study is looking at ways to help people who have had a specific type of stroke called aSAH by using a new tool to keep an eye on blood flow in the brain, so doctors can quickly spot any problems and take action to help prevent serious complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | December 12, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $459,963 |
| NIH project number | 5R01NS135077-02 |
| Project ID | NIH-11000302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered an aneurysmal subarachnoid hemorrhage.
✕Less likely to help
Patients who have not experienced aSAH or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke caused by the rupture of an intracranial aneurysm. The study aims to develop a noninvasive method to continuously monitor brain blood flow and identify patients at risk for delayed cerebral ischemia (DCI), a serious complication that can lead to poor outcomes. By using a novel optical instrument called Pathlength Resolved Diffuse Correlation Spectroscopy (PR-DCS), researchers hope to provide real-time data that can help clinicians make timely interventions. This approach seeks to improve patient management and outcomes following aSAH.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for patients recovering from aSAH, potentially reducing the incidence of serious complications.
How similar studies have gone: Previous research has shown promise in using noninvasive monitoring techniques for cerebrovascular conditions, suggesting potential success for this novel approach.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Mokin, Maxim — University of South Florida
- Study coordinator: Mokin, Maxim
Related research
Other NIH-funded projects on the same topics.
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Cognitive screening after an aneurysmal brain bleed
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
-
Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
-
3D brain blood vessel model to study subarachnoid hemorrhage and test therapies
A researcher will develop a 3D printed, biomimetic brain model to study subarachnoid hemorrhage and screen potential nanoparticle-based treatments.
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Biomarkers to Fine-Tune Intrathecal Nicardipine for Brain Bleeding-Related Stroke
Researchers are testing biomarkers to personalize intrathecal nicardipine treatment for patients after subarachnoid hemorrhage to prevent brain damage.
-
Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
-
Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.