Monitoring antibiotic levels in critically ill patients undergoing dialysis
Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT
This study is testing a new way to keep track of antibiotic levels in patients with sepsis and kidney issues who are on special dialysis, so doctors can give the right amount of medicine at the right time to help them get better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10763826 on NIH RePORTER |
What this research studies
This research focuses on developing a new technology to continuously monitor antibiotic levels in patients with sepsis-induced acute kidney injury who are receiving continuous renal replacement therapy (CRRT). By using electrochemical aptamer-based sensors, the study aims to provide real-time feedback on drug levels in the bloodstream, allowing for precise dosing of life-saving antibiotics. This approach addresses the challenge of variable drug clearance rates in critically ill patients, potentially improving treatment outcomes. The research will involve translating previous animal studies into clinical applications for human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients diagnosed with sepsis-induced acute kidney injury who are undergoing continuous renal replacement therapy.
Not a fit: Patients who are not critically ill or do not require dialysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer antibiotic dosing for critically ill patients, reducing mortality rates associated with sepsis and acute kidney injury.
How similar studies have performed: Previous research has shown promise in using similar monitoring technologies in animal models, but this approach is novel in the clinical setting for human patients.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Mohan, Sumit — Columbia University Health Sciences
- Study coordinator: Mohan, Sumit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.