Molybdoenzyme Chemistry: How the Mo Cofactor Helps Enzymes Work in Health
Official title: Spectroscopic Studies of Molybdoenzymes & Models
Funded at University of New Mexico · NIH-11386571 · Data updated 2026-11-12
A scientist at a university is studying how molybdenum enzymes work at the molecular level to influence health, using spectroscopy and computer models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | June 1, 1998 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $375,692 |
| NIH project number | 5R01GM057378-26 |
| Project ID | NIH-11386571 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant is basic science research and does not require patient participation; it may inform future patient-focused studies.
✕Less likely to help
Direct patient benefit is not guaranteed during this basic science project.
What this research studies
Researchers will examine how the Mo cofactor and its PDT ligand shape the activity of molybdoenzymes that affect human health. They will use spectroscopic methods alongside computational analyses to map geometric and electronic structures and connect them to catalytic outcomes. The project aims to translate fundamental enzyme chemistry into insights about disease processes and potential therapeutic targets. This work could help explain how certain biological reactions contribute to health and disease. Ultimately, the findings may inform future strategies to improve health outcomes by targeting molybdoenzyme function.
Why it matters
Potential benefit: If successful, the research could lead to better understanding of enzymes linked to human diseases and inform new approaches to diagnosis or treatment.
How similar studies have gone: Previous work shows that studying enzyme structure and reactivity can reveal mechanisms relevant to human health.
Where this research is happening
-
University of New Mexico
Albuquerque, United States Active
Researchers
- Principal investigator: Kirk, Martin L — University of New Mexico
- Study coordinator: Kirk, Martin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.