Molecules that shape memory across the lifespan
Uncovering brain-wide molecular determinants of individual memory performance across lifespan
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-11009687
This project looks for the molecules that help form and preserve memories to better understand why memory changes with aging and Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11009687 on ClinicalTrials.gov |
What this research studies
Researchers use a tiny worm (C. elegans) whose entire nervous system is already mapped to find which genes and molecules change when memories form. They pair memory training with advanced molecular mapping tools that show where and when those molecules act across the whole nervous system and at different ages. The team aims to create a detailed, brain-wide picture of the molecular steps needed for long-term memory and how those steps vary between individuals and over the lifespan. Findings are intended to point to molecular targets that could explain age-related memory loss and Alzheimer's disease.
Who could benefit from this research
Good fit: People with age-related memory problems or early-stage Alzheimer's who want to follow research developments or consider future clinical trials would be the most relevant audience.
Not a fit: Patients seeking immediate treatments or those with non-memory neurological conditions are unlikely to see direct benefits from this basic laboratory research in the short term.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets or markers that lead to treatments or earlier detection for age-related memory decline and Alzheimer's disease.
How similar studies have performed: Previous lab studies using worms and other models have uncovered molecules linked to memory, but translating those findings into human therapies remains early and unproven.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AREY, RACHEL NICOLE — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: AREY, RACHEL NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome