Molecular signs of aging, longevity, and Alzheimer’s across mammals
Multi-omics biomarkers and molecular features of aging, longevity and Alzheimer's disease
['FUNDING_P01'] · UNIVERSITY OF ROCHESTER · NIH-11182552
Using molecular information from many mammal species to find biological signs of aging that could help people with or at risk for Alzheimer’s disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11182552 on ClinicalTrials.gov |
What this research studies
This project compares DNA, proteins, and other molecular markers across a wide range of mammals to find patterns linked to longer life and resistance to Alzheimer’s-like diseases. The team builds and refines “aging clocks” and other biomarkers that estimate biological age from multi-omics data. They apply these tools to understand molecular features that may drive Alzheimer’s disease and related dementias. Over time, the work aims to translate those findings into tools or targets that could be tested in people or patient samples.
Who could benefit from this research
Good fit: Adults aged 21 and older, especially people diagnosed with Alzheimer’s disease or those at increased risk for dementia, would be most relevant to this work.
Not a fit: People seeking an immediate new treatment or those with conditions unrelated to aging or neurodegeneration are unlikely to receive direct benefit from this basic and comparative research.
Why it matters
Potential benefit: If successful, the work could lead to new molecular tests or targets that help detect Alzheimer’s risk earlier or guide treatments to slow age-related brain decline.
How similar studies have performed: Related studies have produced aging ‘clocks’ from human omics data and linked some markers to dementia risk, but applying cross‑species multi-omics to Alzheimer’s is relatively novel.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLADYSHEV, VADIM N. — UNIVERSITY OF ROCHESTER
- Study coordinator: GLADYSHEV, VADIM N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease