Molecular predictors of type 2 diabetes patterns in South Asian adults
Molecular Prediction, Disease Progression, and Type 2 Diabetes (T2D) Phenotypes in South Asians
This project looks for genetic and blood-based signals that help predict which South Asian adults with prediabetes or diabetes will follow different disease paths.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11481326 on NIH RePORTER |
What this research studies
You would be part of research using clinical data and banked blood samples from thousands of South Asian adults followed for over a decade to find molecular markers linked to different types of type 2 diabetes. The team will group people by diabetes traits (for example, insulin-deficient versus insulin-resistant) and compare genetic and metabolite patterns across those groups. They will build models to see which molecular signals predict progression from prediabetes to diabetes and the risk of complications. The aim is to use these findings to guide more personalized prevention and treatment for South Asian patients.
Who could benefit from this research
Good fit: South Asian adults aged 21 and older with prediabetes or type 2 diabetes, especially those already enrolled in the Precision-CARRS cohort or able to provide blood samples and medical records.
Not a fit: People who are not of South Asian ancestry, children, or those with type 1 diabetes are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help doctors predict who among South Asian patients is most likely to develop diabetes or complications and tailor prevention or treatment accordingly.
How similar studies have performed: Prior work has identified diabetes subgroups in European populations and the investigators' preliminary data show a high prevalence of insulin-deficient phenotypes in South Asians, so this is a novel extension with promising early evidence.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.