Molecular mechanisms of lipid transfer by bridge-like lipid transfer proteins
Funded at Oregon State University · NIH-11402824 · Data updated 2026-11-12
A research team will study how bridge-like lipid transfer proteins move fats around cells to support basic cellular functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $399,081 |
| NIH project number | 5R35GM160234-02 |
| Project ID | NIH-11402824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable here; the study uses model organisms and cell systems, not requiring patient participation.
✕Less likely to help
No direct patient benefit from participation is anticipated in this basic science project.
What this research studies
This project aims to uncover how bridge-like lipid transfer proteins move lipids between membranes and how this process affects cell physiology and organelle function. Researchers will use the model organism C. elegans and cell lines to characterize the proteins’ structure, interactions, and lipid transfer mechanisms. The work will involve advanced imaging, biochemistry, and genetics to link BLTP activity with cellular health and disease implications. Findings could clarify fundamental cellular processes and identify new angles for understanding lipid-related diseases.
Why it matters
Potential benefit: Could improve understanding of cellular lipid transport, potentially informing therapies for diseases linked to BLTP dysfunction.
How similar studies have gone: Previous work has begun to reveal BLTP structures and functions, but many questions remain about their mechanisms and disease links.
Where this research is happening
-
Oregon State University
Corvallis, United States Active
Researchers
- Principal investigator: Clark, Sarah a — Oregon State University
- Study coordinator: Clark, Sarah a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.