Molecular mechanisms in the mammalian cell nucleus (for patients)
Official title: Molecular mechanisms in the mammalian cell nucleus
Funded at Rice University · NIH-11384220 · Data updated 2026-11-12
Researchers study the tiny structures inside human cells to understand how they work and what goes wrong in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $364,385 |
| NIH project number | 5R35GM155365-03 |
| Project ID | NIH-11384220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with cancers or related conditions whose cells or tissues could be studied to understand nuclear dynamics and gene regulation.
✕Less likely to help
People not involved in cell or tissue studies or those without access to related research materials may not directly benefit.
What this research studies
This project uses advanced imaging tools to watch molecules inside human cell nuclei in real time, aiming to reveal how genes are controlled and how changes in the nucleus contribute to cancer and other diseases. The team will develop and apply 3D, high-resolution imaging and analysis methods to track chromatin and nuclear proteins in living cells. Results could illuminate new targets for therapies by showing how nucleus dynamics affect disease progression. Participation would involve advanced imaging in lab-based studies using human cell samples or models, with careful attention to safety and consent where human material is used.
Why it matters
Potential benefit: If successful, the research could lead to better understanding of cancer biology and gene regulation, potentially guiding new diagnostic or treatment approaches.
How similar studies have gone: Previous studies using advanced imaging have revealed important nuclear processes; this project builds on proven techniques but applies them to more detailed 3D analyses.
Where this research is happening
-
Rice University
Houston, United States Active
Researchers
- Principal investigator: Gustavsson, Anna Karin Eva — Rice University
- Study coordinator: Gustavsson, Anna Karin Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.