Molecular fingerprints to predict who develops long-term pain
Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS) Program
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11168927
This project will look at blood and other samples from adults after surgery or injury to find molecular signs that predict who will go on to have chronic pain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11168927 on ClinicalTrials.gov |
What this research studies
If you join, researchers will follow adults after a defined surgery or musculoskeletal injury and collect clinical data and biofluid samples soon after the event and again at 3 and 6 months. Labs will generate multiple types of molecular (multi-omics) data from those samples to test 40 pre-selected markers and to discover new candidate markers. The goal is to find patterns that distinguish people who recover from those who develop chronic pain. Results could guide earlier, targeted prevention or monitoring for people at higher risk.
Who could benefit from this research
Good fit: Adults (21 years and older) who have a specific acute painful surgery or musculoskeletal trauma and can attend sample collection at baseline, 3 months, and 6 months are ideal candidates.
Not a fit: People under 21, those without a recent qualifying acute injury/surgery, or people who already have chronic pain before the event are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, the work could help identify people at high risk for chronic pain so they can get earlier, personalized prevention or treatment.
How similar studies have performed: Smaller studies have suggested candidate molecular markers for chronic pain risk, but large multi-site multi-omics validation like this is new.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAURENT, LOUISE CHANG — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: LAURENT, LOUISE CHANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.