Molecular details of how early beta-amyloid disrupts neuronal membranes
Official title: Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide Aggregation
Funded at State University of Ny,binghamton · NIH-11319353 · Data updated 2026-11-12
Aims to replace a broken lab HPLC system to help study how early beta-amyloid peptides may disrupt neuron membranes in Alzheimer’s disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $58,302 |
| NIH project number | 3R01GM125853-08S1 |
| Project ID | NIH-11319353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a direct patient study; however, advances could benefit individuals with Alzheimer’s disease in the long term.
✕Less likely to help
Direct patient participation is not part of this grant.
What this research studies
This project focuses on understanding how beta-amyloid peptides begin to disrupt neuronal membranes at the molecular level. It relies on high-purity synthetic Ab peptides and a functioning HPLC system to purify and analyze these peptides, which is essential for accurate experiments. By repairing and updating the lab equipment, the team hopes to generate clearer data that could inform future therapeutic approaches for Alzheimer’s disease.
Why it matters
Potential benefit: Improved understanding of early amyloid events could guide development of targeted therapies for Alzheimer’s disease.
How similar studies have gone: Previous work shows that clean peptide purification improves the reliability of molecular studies on amyloid–membrane interactions.
Where this research is happening
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State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Qiang, Wei — State University of Ny,binghamton
- Study coordinator: Qiang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.