Molecular details of how early amyloid builds damage neuronal membranes in Alzheimer’s
Official title: Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide Aggregation
Funded at State University of Ny,binghamton · NIH-11392478 · Data updated 2026-11-12
Researchers are studying how early clumps of amyloid protein mess with brain cell membranes in Alzheimer’s disease to better understand why membrane damage happens.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $359,186 |
| NIH project number | 5R01GM125853-08 |
| Project ID | NIH-11392478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing trial; findings may inform future interventions for people with Alzheimer’s disease.
✕Less likely to help
Direct participant benefits are not part of this basic science grant.
What this research studies
This project uses advanced solid-state NMR to look at how amyloid-β peptides interact with neuronal membranes in environments that resemble real brain cells. By focusing on the initial aggregation steps and the surrounding lipids, the study aims to map the structural features that cause membrane disruption over time. The work builds on prior findings about different membrane-damaging pathways and uses model liposomes and neuronal cells to observe these processes in detail. The goal is to reveal precise molecular interactions that could inform later therapies targeting membrane integrity in Alzheimer’s disease.
Why it matters
Potential benefit: A clearer picture of how amyloid causes membrane damage could guide future treatments aimed at protecting neurons in Alzheimer’s disease.
How similar studies have gone: Previous work has shown membrane disruption pathways, suggesting this line of inquiry could extend that knowledge.
Where this research is happening
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State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Qiang, Wei — State University of Ny,binghamton
- Study coordinator: Qiang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.