Molecular control of β2 integrin activation in neutrophil adhesion and inflammation
Official title: Molecular regulation of β2 integrin activation in neutrophil adhesion and inflammation
Funded at University of Nevada Reno · NIH-11392966 · Data updated 2026-11-12
This grant explores how neutrophils use β2 integrins to stick to blood vessels during inflammation, with the aim of reducing inflammatory damage in cardiovascular disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $546,496 |
| NIH project number | 5R01HL174533-03 |
| Project ID | NIH-11392966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with inflammatory cardiovascular conditions or a willingness to contribute samples or data in future translational studies, via related clinical programs or trials.
✕Less likely to help
As this is primarily a basic science study in animals, direct patient benefit during the grant is unlikely.
What this research studies
The project investigates how proteins called kindlin-3 and talin-1 work together to activate β2 integrins on neutrophils, which helps these white blood cells move into damaged tissues. Researchers will use specially engineered mouse models to watch β2 integrin activation and visualize kindlin-3 and talin-1 in real time. By testing the mechanisms that control this activation, the study aims to identify ways to blunt excessive inflammation and ischemia-reperfusion injury. The findings could point toward new targets to limit tissue damage after heart attack or stroke. This work is grounded in basic biology but has clear implications for therapies that reduce cardiovascular inflammation.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to prevent or lessen inflammatory damage in cardiovascular diseases.
How similar studies have gone: Prior work shows that targeting β2 integrin activation can modulate inflammatory responses, supporting the potential for meaningful translation.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Wen, Lai — University of Nevada Reno
- Study coordinator: Wen, Lai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.