Molecular clues for congenital hydrocephalus in diverse patients
Official title: Molecular and cellular characterization of congenital hydrocephalus
Funded at Washington University · NIH-11180382 · Data updated 2026-11-12
A patient-facing look at a research project to understand why congenital hydrocephalus occurs and why it affects some children more than others, with a focus on diverse early-life genes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $622,741 |
| NIH project number | 5R01NS131610-02 |
| Project ID | NIH-11180382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with congenital hydrocephalus, especially from non-European backgrounds, and their families.
✕Less likely to help
Children without CH or those not contributing data or samples would not directly benefit.
What this research studies
This project aims to build a large, diverse group of children with congenital hydrocephalus and study their genes, brain imaging, and clinical outcomes. Researchers will combine genetic data, brain scans, and clinical records to identify patterns that explain why ventriculomegaly and neurodevelopmental issues occur after surgery. The goal is to uncover new gene clues and how non-European populations are affected, to guide better diagnoses and future therapies. Participants or their families may contribute blood samples and imaging data to help map the condition at the molecular and cellular level.
Why it matters
Potential benefit: In the future, findings could lead to more accurate diagnoses and personalized treatments that improve brain development and outcomes for children with CH.
How similar studies have gone: Previous research has identified CH risk genes, but most studies lack diverse populations and comprehensive multi-modal data.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Jin, Sheng Chih — Washington University
- Study coordinator: Jin, Sheng Chih
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.