Molecular causes of aggressive gastrointestinal stromal tumors (GIST)
Project 1: Molecular Determinants of GIST Pathogenesis
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11181584
Looking at tumor genes to understand why some gastrointestinal stromal tumors (GIST) become aggressive or spread in people with GIST.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11181584 on ClinicalTrials.gov |
What this research studies
You or other people with GIST could have tumor DNA and clinical information analyzed to find genetic changes linked to aggressive or metastatic disease. Researchers compare genetic profiles from many patients' primary and metastatic tumors, searching for changes such as loss of MAX or MGA, MYC amplification, and chromosome deletions. They link those genetic changes to outcomes like relapse after surgery to identify markers that signal higher risk. The team plans to validate these markers so doctors can eventually use them to guide follow-up and treatment.
Who could benefit from this research
Good fit: Ideal participants are people with GIST who can provide tumor tissue or clinical records, especially those newly diagnosed, untreated, or with samples from both primary and metastatic tumors.
Not a fit: People without available tumor tissue, those with other types of cancer, or whose tumors lack the specific genetic changes studied may not see direct benefit from this project.
Why it matters
Potential benefit: If successful, this could identify genetic markers that help predict which GIST tumors are likely to come back or spread and improve treatment and follow-up choices.
How similar studies have performed: Previous genomic analyses, including a large MSK cohort, have found similar gene changes linked to worse outcomes, but using these markers in routine care remains new.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHI, PING — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: CHI, PING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers