Molecular basis of nuclear pore formation in aging and neurodegeneration
Official title: Molecular Basis of Nuclear Pore Formation
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11430287 · Data updated 2026-11-12
This NIH grant studies how the tiny gateways in cells (nuclear pores) form and malfunction in aging and diseases like Alzheimer’s and ALS, with the hope of better understanding disease processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,903,176 |
| NIH project number | 1R01GM166538-01 |
| Project ID | NIH-11430287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing recruitment study; findings may inform future approaches for people with aging or neurodegenerative diseases.
✕Less likely to help
This grant does not recruit patients or provide direct treatment.
What this research studies
Researchers will investigate how nuclear pore complexes are built in human cells and how lipid metabolism and RNA splicing affect their assembly. Using a combination of genome-wide screens, molecular biology, and cell-based assays, the project aims to map the factors that regulate pore formation and how these changes relate to aging and neurodegenerative disease. The work could reveal new targets to protect cells from damage in conditions such as Alzheimer’s disease by preserving genome integrity and healthy nuclear transport.
Why it matters
Potential benefit: Better understanding of how nuclear pores malfunction in aging and Alzheimer’s could lead to new strategies to protect brain cells.
How similar studies have gone: Prior work links nuclear pore defects to aging and neurodegenerative disorders, suggesting this approach may yield meaningful insights.
Where this research is happening
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Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Dangelo, Maximiliano a — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Dangelo, Maximiliano a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.