Modulating genes linked to aging using targeted therapies
Official title: Targeted Modulation of Longevity-Associated Genes Using Antisense Oligonucleotides
Funded at Saint Louis University · NIH-10952503 · Data updated 2026-11-12
This study is exploring a new way to use special molecules to change how certain genes related to aging work, with the hope of helping mice live longer and healthier lives, which could lead to better understanding for people on how to slow down aging and improve health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $416,625 |
| NIH project number | 1R21AG088932-01 |
| Project ID | NIH-10952503 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals at risk for age-related diseases or those interested in longevity and healthspan improvement.
✕Less likely to help
Patients with acute conditions unrelated to aging or those who are not experiencing age-related health issues may not receive any benefit from this research.
What this research studies
This research investigates how to use antisense oligonucleotides (ASOs) to specifically target and modify the expression of genes associated with aging. By designing ASOs for four key longevity-related genes, the project aims to determine if these modifications can extend lifespan and enhance healthspan in a mouse model that simulates accelerated aging. Patients may benefit from insights gained about how to slow aging-related diseases and improve overall health as a result of this work.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow the aging process and improve health in older adults.
How similar studies have gone: Other research has shown promise in using antisense oligonucleotides for gene modulation, indicating potential for success in this novel approach.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Nguyen, Andrew D. — Saint Louis University
- Study coordinator: Nguyen, Andrew D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.