Modulating brain circuits to treat Alzheimer's disease
Glutamatergic neural circuit modulation for treating Alzheimer’s disease
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10891762
This study is exploring how changing certain brain pathways might help improve memory and slow down Alzheimer's disease, especially in its early stages, by boosting the activity of healthier brain cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10891762 on ClinicalTrials.gov |
What this research studies
This research investigates how altering specific neural circuits in the brain can help treat Alzheimer's disease, which leads to memory loss. The approach focuses on restoring the function of vulnerable brain circuits during the early stages of the disease, potentially reversing memory impairment. By stimulating certain neurons that are less affected by the disease, the research aims to enhance memory performance and slow down the progression of Alzheimer's. The methodology includes advanced techniques to monitor brain activity and assess memory function in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals in the early stages of Alzheimer's disease who are experiencing memory loss.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory and slow the progression of Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using similar approaches to modulate brain circuits for cognitive improvement, indicating potential for success in this area.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SONG, JUAN — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SONG, JUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease