Modulating a brain receptor to help with PTSD and alcohol abuse
mGlu5 modulation prevents and attenuates deficits in a model of PTSD/AUD comorbidity
This study is looking at how PTSD and alcohol use problems are connected in Veterans, and it aims to find new ways to help improve thinking and decision-making by looking at how the brain works, which could lead to better treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James H Quillen VA Medical Center NIH-funded |
| Lab location | 1 site (Mountain Home, United States) |
| Project ID | NIH-11098478 on NIH RePORTER |
What this research studies
This research investigates the relationship between post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD), particularly in Veterans who are at a higher risk for both conditions. The study aims to understand how changes in brain function affect behavior and decision-making in individuals with these disorders. By exploring innovative approaches to modulate specific brain receptors, the research seeks to identify potential treatments that could improve cognitive flexibility and reduce the severity of symptoms associated with PTSD and AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans experiencing symptoms of PTSD and alcohol use disorder.
Not a fit: Patients without PTSD or alcohol use disorder may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that help individuals with PTSD and alcohol use disorder manage their symptoms more effectively.
How similar studies have performed: Previous research has shown promise in using similar approaches to address comorbid mental health disorders, indicating potential for success in this area.
Where this research is happening
Mountain Home, United States
- James H Quillen VA Medical Center — Mountain Home, United States (Active)
Researchers
- Principal investigator: Gass, Justin T — James H Quillen VA Medical Center
- Study coordinator: Gass, Justin T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.