Modified cardiac rehabilitation to improve physical and emotional recovery after stroke

Modified cardiac rehabilitation to enhance post-stroke physical and psychosocial function: does despression limit the response?

NIH-funded research Medical University of South Carolina · NIH-11262869

A tailored cardiac rehabilitation program uses progressive aerobic and strength exercise to help people recovering from stroke improve fitness, daily function, and mood.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMedical University of South Carolina NIH-funded
Lab location1 site (Charleston, United States)
Project IDNIH-11262869 on NIH RePORTER

What this research studies

You would take part in a cardiac-style rehab program adapted for stroke survivors with guided aerobic and strengthening sessions at a higher, progressive intensity. The program is designed to be scalable and to complement usual stroke therapy by focusing on walking, balance, and activities of daily living. Staff will track changes in aerobic fitness, mobility, day-to-day function, and emotional health, and they will examine whether having depression limits how much people improve. The aim is to create a practical exercise pathway that can be offered alongside standard stroke care.

Who could benefit from this research

Good fit: Adults who have survived a stroke, are medically stable, have reduced aerobic fitness or functional limitations, and can participate in supervised exercise would be ideal candidates.

Not a fit: People with unstable cardiac conditions, severe cognitive or medical impairments that prevent safe exercise participation, or those unable to attend supervised sessions may not benefit from this program.

Why it matters

Potential benefit: If successful, this approach could help stroke survivors regain aerobic fitness, move better in daily life, and feel less socially or emotionally impaired.

How similar studies have performed: Earlier small trials and pilot programs using modified cardiac rehab for stroke have shown promise in improving aerobic capacity and walking, but larger definitive trials are limited.

Where this research is happening

Charleston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.