Models to predict the best flu vaccine strains
Predictive fitness models for influenza vaccine strain selection
This study is looking at how our immune system responds to the flu virus, which changes quickly, to help predict which flu strains will be most common next season, so we can choose better vaccine options to keep you protected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11000769 on NIH RePORTER |
What this research studies
This research focuses on understanding how the human immune system interacts with the influenza virus, which changes rapidly to evade immunity. By developing computational models, the project aims to predict which strains of the flu virus are likely to dominate in the upcoming flu season. This involves analyzing the genetic and antigenic diversity of circulating viruses and how they relate to the immunity present in the human population. The goal is to improve the selection of vaccine strains to enhance protection against influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for influenza, including those with weakened immune systems, the elderly, and young children.
Not a fit: Patients who are not at risk for influenza or those who have already received a flu vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective flu vaccines that better match circulating virus strains, ultimately reducing flu-related illnesses and hospitalizations.
How similar studies have performed: Other research has shown promise in using computational models to predict viral evolution and improve vaccine strain selection, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Luksza, Marta — Icahn School of Medicine at Mount Sinai
- Study coordinator: Luksza, Marta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.