Modeling the effects of genetic mutations on molecular processes
Official title: DelPhi and associated resources: maintenance, development and applications
Funded at Clemson University · NIH-11019803 · Data updated 2026-11-12
This study is exploring how changes in genes can lead to health issues by using computer tools to see how these changes affect proteins and other important molecules, and it's designed for anyone interested in understanding genetic disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $341,114 |
| NIH project number | 5R35GM151964-02 |
| Project ID | NIH-11019803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders linked to missense mutations.
✕Less likely to help
Patients with genetic conditions not related to missense mutations may not benefit from this research.
What this research studies
This research focuses on using computational methods to understand how disease-causing mutations in genes affect the stability and function of proteins, RNAs, and DNAs. By developing software and web tools, the team aims to model various biological processes and predict how specific mutations can lead to genetic disorders. The research involves collaboration with experimental labs to validate findings and improve the accuracy of their models. The team has a strong background in structural biology and has previously achieved recognition for their predictive capabilities in molecular biology.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for genetic disorders caused by mutations.
How similar studies have gone: Previous research in computational biophysics and bioinformatics has shown success in modeling genetic mutations and their effects on diseases.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Alexov, Emil Georgiev — Clemson University
- Study coordinator: Alexov, Emil Georgiev
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.