Modeling strategies to prevent and control uterine cancer
Official title: Comparative Modeling for the Prevention and Control of Uterine Cancer
Funded at Columbia University Health Sciences · NIH-10926837 · Data updated 2026-11-12
This study is looking at ways to better prevent, screen for, and treat uterine cancer, especially for women from different racial backgrounds, so that doctors and health leaders can make smarter choices about care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $803,402 |
| NIH project number | 5U01CA265739-04 |
| Project ID | NIH-10926837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women at risk for uterine cancer, particularly those from racial minority backgrounds who may face higher mortality rates.
✕Less likely to help
Patients who do not have a risk of developing uterine cancer or those who are already in advanced stages of the disease may not benefit from this research.
What this research studies
This research focuses on understanding and improving the prevention, screening, and treatment of uterine cancer, which is increasingly affecting women, particularly those from racial minority groups. By developing natural history models that incorporate various risk factors and population changes, the research aims to provide insights into effective cancer control strategies. The collaborative effort involves multiple groups working together to analyze both favorable and aggressive forms of uterine cancer, ultimately guiding clinicians and policymakers in making informed decisions about screening and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for uterine cancer, potentially reducing mortality rates and improving outcomes for affected women.
How similar studies have gone: Previous research has shown success in using modeling approaches to inform cancer prevention and control strategies, indicating that this methodology is both promising and relevant.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wright, Jason — Columbia University Health Sciences
- Study coordinator: Wright, Jason
Related research
Other NIH-funded projects on the same topics.
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Modeling to Prevent and Control Uterine Cancer
A national modeling effort uses computer simulations to inform better prevention, screening, and treatment of uterine cancer for women.
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Comparative modeling to guide uterine cancer care
This grant uses computer models to help doctors and patients understand how to make better decisions about uterine cancer care.
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Using DNA damage drugs to help the immune system fight uterine cancer
This project combines drugs that increase tumor DNA damage with immunotherapy to help people with recurrent microsatellite-stable uterine cancer who haven't responded to current treatments.
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Dual ATR and PI3K-targeted therapy for uterine cancer
This project will try combining two drugs that block ATR and PI3K to better stop uterine cancers, especially tumors with ARID1A changes or other DNA replication stress.
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WEE1-targeted treatment for uterine serous and p53-mutant uterine cancer
Testing a drug that blocks the WEE1 protein to try to shrink uterine serous cancers and other uterine cancers with p53 mutations.
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Treating uterine (endometrial) cancer by targeting DNA damage and replication stress
This project develops new treatment approaches that exploit DNA repair weaknesses to help women with advanced or recurrent uterine (endometrial) cancer who need additional options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.