Modeling stomach precancerous lesions and how H. pylori affects them
Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions
This project uses lab-grown human stomach tissue to learn which precancerous lesions and stem cells in people with gastric intestinal metaplasia are most likely to progress toward cancer, especially when infected with Helicobacter pylori.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11179409 on NIH RePORTER |
What this research studies
The team grows small, patient-derived stomach tissues called organoids that mimic precancerous changes in the stomach. They will create a library of organoids from different stomach locations and use sequencing and advanced microscopy to profile the stem cells in high-risk lesions. Selected gene changes found in other parts of the project will be introduced with CRISPR to see how those alterations change cell behavior. Finally, the researchers will expose these organoids to H. pylori to study how infection influences progression toward cancer.
Who could benefit from this research
Good fit: People with gastric intestinal metaplasia or other precancerous stomach lesions who can provide biopsy tissue during endoscopy would be ideal candidates for contributing samples to this work.
Not a fit: People without stomach precancerous changes or unrelated digestive conditions are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help doctors identify which precancerous stomach lesions are most likely to become cancer and guide more personalized monitoring or prevention.
How similar studies have performed: Patient-derived organoids and H. pylori interactions have been studied before, but combining apical-out gastric organoids with CRISPR modeling of high-risk lesion genetics is a relatively new and translational approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Amieva, Manuel R — Stanford University
- Study coordinator: Amieva, Manuel R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.