Modeling muscle problems caused by statins using patient-derived cells
Patient-specific modeling of metabolic dysfunction in statin-induced myopathy using iPSC-derived myocytes
['FUNDING_CAREER'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-11017376
This study is looking at how statin medications might cause muscle pain and weakness by using special cells from patients to better understand the problem, and if you join, you could help find personalized treatments that work for you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-11017376 on ClinicalTrials.gov |
What this research studies
This research investigates how statin medications can lead to muscle dysfunction by creating patient-specific models using induced pluripotent stem cells (iPSCs) derived from myocytes. The approach involves analyzing these cells to understand the underlying mechanisms of statin-induced myopathy, which can cause muscle pain and weakness. By using advanced techniques like CRISPR, researchers aim to identify genetic factors that contribute to this condition and explore potential therapeutic strategies. Patients may have the opportunity to contribute their cells to help develop personalized treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience muscle pain or weakness while on statin therapy.
Not a fit: Patients who do not take statins or do not experience muscle-related side effects from these medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of muscle-related side effects in patients taking statins.
How similar studies have performed: Other research has shown promise in using patient-derived cells to study drug-induced side effects, indicating that this approach could yield valuable insights.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RHEE, JUNE-WHA — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: RHEE, JUNE-WHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.