Modeling mouse arm movements after brain injury
Official title: Computational Modeling of Mouse Forelimb Movements
Funded at University of Colorado Denver · NIH-10931983 · Data updated 2026-11-12
This study is exploring how the movements of a mouse's front legs are managed by the brain, especially after a stroke, to help us understand better ways to support recovery and movement in animals and potentially in people too.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $378,800 |
| NIH project number | 1R01DA060790-01 |
| Project ID | NIH-10931983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would include individuals recovering from strokes or other neurological conditions affecting motor function.
✕Less likely to help
Patients with conditions unrelated to motor control or those not recovering from neurological injuries may not receive benefit from this research.
What this research studies
This research focuses on understanding how mouse forelimb movements are controlled, particularly after brain injuries like strokes. By creating advanced computational models, the team aims to simulate and predict muscle activity and movement patterns that are challenging to measure directly. The study will utilize artificial neural networks and physics-based simulations to analyze the relationship between movement and brain activity, potentially reducing the need for extensive animal experiments. The findings could provide valuable insights into motor control mechanisms and rehabilitation strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of motor control after brain injuries, potentially informing rehabilitation techniques for patients.
How similar studies have gone: Other research has shown promise in using computational models to understand motor control, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Al Borno, Mazen — University of Colorado Denver
- Study coordinator: Al Borno, Mazen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.