Modeling Lennox-Gastaut Syndrome to Improve Neurobehavioral Outcomes
Official title: Modeling Lennox-Gastaut Syndrome for improved clinical and neurobehavioral outcomes
Funded at New York Medical College · NIH-11416171 · Data updated 2026-11-12
A research project at New York Medical College is studying Lennox-Gastaut syndrome to help reduce seizures and improve thinking and behavior in affected people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $406,620 |
| NIH project number | 4R33NS140683-02 |
| Project ID | NIH-11416171 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Lennox-Gastaut syndrome or related developmental epileptic encephalopathies who could contribute samples or participate in future translational studies.
✕Less likely to help
Patients without LGS or related conditions may not directly benefit from this research.
What this research studies
This project focuses on Lennox-Gastaut syndrome (LGS), a severe epilepsy that starts in childhood and often leads to ongoing cognitive and behavioral challenges. The team plans to use models to understand how LGS develops and to test potential strategies that could lessen seizures and improve daily functioning. Researchers will examine how different treatments might impact neurobehavioral outcomes, with the goal of finding approaches that could benefit patients now and in the future. Participation would involve advancing knowledge that could translate into better therapies for people living with LGS.
Why it matters
Potential benefit: If successful, the work could lead to more effective treatments that lessen seizures and improve cognitive and behavioral outcomes for people with LGS.
How similar studies have gone: There is a need for animal and model-based work to translate into human treatments for LGS, and prior efforts have shown promise in related epilepsy research.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Velisek, Libor — New York Medical College
- Study coordinator: Velisek, Libor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.