Modeling immune responses in tumor organoids to improve cancer treatment
Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments
This study is looking at how cancer cells and immune cells work together using special lab-grown mini tumors from patients, to find out how well different treatments, like anti-PD-1 antibodies, can help the immune system fight cancer, which could lead to better therapies for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11035173 on NIH RePORTER |
What this research studies
This research investigates how tumor cells interact with the immune system using advanced organoid technology. By creating patient-derived tumor organoids that include both tumor cells and immune cells, researchers aim to better understand the immune response to cancer therapies like anti-PD-1 antibodies. The organoids preserve the original tumor's characteristics and allow for testing how well immune cells can attack the tumor when exposed to various treatments. This approach could lead to more effective immunotherapies by identifying which patients are likely to respond to specific treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that can be biopsied and who are undergoing immunotherapy treatments.
Not a fit: Patients with tumors that are not amenable to biopsy or those who are not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective cancer immunotherapies for patients.
How similar studies have performed: Previous research has shown success with similar organoid models in understanding tumor-immune interactions, indicating a promising approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Kuo, Calvin J — Stanford University
- Study coordinator: Kuo, Calvin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.