Modeling how immune receptors recognize antigens
High resolution modeling and design of immune recognition
This study is working on better ways to understand how our immune system's T cell receptors and antibodies recognize germs, with the hope that this will help create more effective treatments for diseases that affect our immune responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-10993618 on NIH RePORTER |
What this research studies
This research focuses on improving the modeling of immune receptors, specifically T cell receptors and antibodies, which play a crucial role in recognizing antigens. By developing advanced algorithms and utilizing large datasets, the project aims to enhance the accuracy of predicting how these immune receptors bind to various antigens. This could lead to better therapeutic strategies for diseases that involve immune responses. The research employs computational biology techniques, including geometric deep learning, to refine these models and improve their predictive capabilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve immune responses, such as autoimmune diseases or cancers that affect the immune system.
Not a fit: Patients with conditions unrelated to immune receptor interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases by improving our understanding of immune receptor interactions.
How similar studies have performed: Similar research approaches have shown promise in improving immune receptor modeling, indicating a potential for success in this area.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Pierce, Brian G. — Univ of Maryland, College Park
- Study coordinator: Pierce, Brian G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.