Modeling how epigenetic mechanisms regulate gene expression in human cells
Official title: DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
Funded at University of Texas Dallas · NIH-11043483 · Data updated 2026-11-12
This study is exploring how tiny changes in our genes affect how they work in individual human cells, using special tools to help scientists understand these processes better, which could lead to new insights for people interested in genetics and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $294,647 |
| NIH project number | 1R01GM157608-01 |
| Project ID | NIH-11043483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases where epigenetic regulation plays a significant role.
✕Less likely to help
Patients with conditions unrelated to epigenetic mechanisms may not receive any benefit from this research.
What this research studies
This research investigates the complex interactions of epigenetic mechanisms that influence gene expression in human cells. By developing a theoretical and computational framework, the project aims to create predictive models that accurately represent these regulatory networks at the single-cell level. The approach involves assembling and integrating CRISPR-based epigenetic regulators into human cells, allowing researchers to gather extensive data on how these mechanisms operate. Through a combination of theoretical analysis and experimental validation, the study seeks to uncover general principles governing epigenetic regulation.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and manipulation of gene expression, potentially benefiting treatments for various genetic disorders.
How similar studies have gone: Previous research has shown promise in using CRISPR technology for gene regulation, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Bleris, Leonidas — University of Texas Dallas
- Study coordinator: Bleris, Leonidas
Related research
Other NIH-funded projects on the same topics.
-
Profilin as a Target to Normalize Tumor Vessels in Kidney Cancer
A new approach aims to curb blood vessel growth in a common kidney cancer by targeting a protein called Profilin 1 to improve how blood vessels form in tumors.
-
Ultrafast debinding for chairside 3D-printed zirconia dental restorations
A new ultrafast debinding method aims to dramatically shorten how quickly chairside 3D-printed zirconia dental crowns can be made.
-
Adolescents learning about themselves through friends and how it links to mood
A study with teens will test how feedback from close friends and strangers shapes their self-views and mood, using brain and behavior measurements.
-
Bilingual children with developmental language disorder: how two languages shape brain development
A study with bilingual kids who have developmental language disorder to see how knowing two languages affects their brain and language skills.
-
BET inhibitors as a potential therapy for solitary fibrous tumor (SFT)
Aimed at adults with solitary fibrous tumor, this grant explores BET inhibitors to block tumor-driving gene activity.
-
Estrogen, puberty, and early signs of psychosis in teens
This grant looks at how rising estrogen during puberty in girls may influence early brain changes and psychotic-like experiences as kids become teens.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.