Modeling how epigenetic mechanisms regulate gene expression in human cells
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
This study is exploring how tiny changes in our genes affect how they work in individual human cells, using special tools to help scientists understand these processes better, which could lead to new insights for people interested in genetics and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11043483 on NIH RePORTER |
What this research studies
This research investigates the complex interactions of epigenetic mechanisms that influence gene expression in human cells. By developing a theoretical and computational framework, the project aims to create predictive models that accurately represent these regulatory networks at the single-cell level. The approach involves assembling and integrating CRISPR-based epigenetic regulators into human cells, allowing researchers to gather extensive data on how these mechanisms operate. Through a combination of theoretical analysis and experimental validation, the study seeks to uncover general principles governing epigenetic regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases where epigenetic regulation plays a significant role.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and manipulation of gene expression, potentially benefiting treatments for various genetic disorders.
How similar studies have performed: Previous research has shown promise in using CRISPR technology for gene regulation, indicating that this approach may yield valuable insights.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Bleris, Leonidas — University of Texas Dallas
- Study coordinator: Bleris, Leonidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.