Modeling how drugs are absorbed in the nasal cavity
Official title: Subject specific modeling of drug absorption in nasal cavity
Funded at Morgan State University · NIH-11064031 · Data updated 2026-11-12
This study is looking at ways to make nasal sprays for chronic rhinosinusitis work better, so patients can get more relief from their symptoms with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morgan State University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $152,437 |
| NIH project number | 5R16GM153629-02 |
| Project ID | NIH-11064031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic rhinosinusitis, particularly those who have not found relief with current treatment options.
✕Less likely to help
Patients with conditions unrelated to chronic rhinosinusitis or those who do not respond to intranasal treatments may not benefit from this research.
What this research studies
This research focuses on chronic rhinosinusitis (CRS), a common condition that significantly affects patients' quality of life. It aims to improve drug delivery methods for treating CRS by using computational fluid dynamics (CFD) to model how medications are absorbed in the nasal cavity. By understanding airflow and drug deposition patterns, the research seeks to enhance the effectiveness of intranasal corticosteroid sprays while minimizing side effects. Patients may benefit from more effective treatments that target the underlying inflammation associated with CRS.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for chronic rhinosinusitis, enhancing patients' quality of life.
How similar studies have gone: Previous research using computational fluid dynamics has shown promise in improving drug delivery methods, suggesting potential success for this approach.
Where this research is happening
-
Morgan State University
Baltimore, United States Active
Researchers
- Principal investigator: Li, Zheng — Morgan State University
- Study coordinator: Li, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.