Modeling how antibodies protect against influenza
Official title: Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
Funded at Duke University · NIH-11016775 · Data updated 2026-11-12
This study is looking at how our body's antibodies fight off the flu, so researchers can create better vaccines that work well for everyone, helping to keep you safe from seasonal and pandemic flu strains.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | December 19, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,082,429 |
| NIH project number | 1U01AI186999-01 |
| Project ID | NIH-11016775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at high risk for influenza, such as the elderly, immunocompromised patients, and those with chronic health conditions.
✕Less likely to help
Patients who are not at risk for influenza or those who have already received effective vaccination may not benefit from this research.
What this research studies
This research aims to develop advanced computational models to predict how antibodies respond to influenza viruses. By analyzing extensive data from infections and vaccinations, the team will create simulations that help understand how a diverse mix of antibodies can provide better protection against the flu. The goal is to improve vaccine effectiveness by identifying the best antibody responses needed to combat seasonal and pandemic influenza strains. Patients may benefit from insights that lead to more effective vaccines tailored to their immune responses.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective influenza vaccines that provide better protection against both seasonal and pandemic strains.
How similar studies have gone: Other research has shown promise in using computational models to enhance vaccine development, indicating that this approach could lead to significant advancements in flu prevention.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Chan, Cliburn C — Duke University
- Study coordinator: Chan, Cliburn C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.