Modeling cerebrospinal fluid flow to find early signs of Alzheimer's disease
Patient specific computational modeling of fluid-structure interactions of cerebrospinal fluid for biomarkers in Alzheimer's disease
This study is looking to create a new way to understand how fluid moves in the brain of people with Alzheimer's disease, using special MRI scans to help spot early signs of the condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10644281 on NIH RePORTER |
What this research studies
This research aims to develop a non-invasive computational model that simulates the flow of cerebrospinal fluid (CSF) and its interaction with brain tissue in patients with Alzheimer's disease. By using advanced MRI scans and patient-specific computational fluid dynamics, the study seeks to quantify how CSF flow is affected by changes in brain tissue stiffness, which may be linked to the early development of Alzheimer's pathology. The goal is to create a reliable method for early detection of Alzheimer's by analyzing these fluid-structure interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of Alzheimer's disease, potentially improving patient outcomes and treatment options.
How similar studies have performed: Other research has shown promise in using non-invasive imaging techniques to study cerebrospinal fluid dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Fillingham, Patrick — University of Washington
- Study coordinator: Fillingham, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.