Modeling brain networks in epilepsy to improve surgery outcomes
Official title: Epileptic Electrophysiological Brain Networks Modeling with Partially Observable Brain Regions
Funded at The Trustees of the Stevens Institute of Technology · NIH-10989176 · Data updated 2026-11-12
This study is looking at how seizures happen in epilepsy by examining how different parts of the brain work together, and it aims to create a new way to pinpoint the exact areas causing the seizures, which could help improve surgery options for people who don’t respond to medication.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Trustees of the Stevens Institute of Technology NIH-funded |
| Lab location | 1 site (Hoboken, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $438,836 |
| NIH project number | 1R21NS135482-01A1 |
| Project ID | NIH-10989176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with drug-resistant epilepsy who are considering surgical options to control their seizures.
✕Less likely to help
Patients whose epilepsy is well-controlled with medication or those who do not qualify for surgery may not benefit from this research.
What this research studies
This research focuses on understanding how seizures in epilepsy arise from coordinated activity across large brain networks. It aims to develop a new computational approach to accurately model these networks, which could help identify the specific brain regions responsible for seizures. By improving the localization of epileptogenic zones, the research seeks to enhance the effectiveness of surgical interventions for patients with drug-resistant epilepsy. The methodology involves advanced simulations and analysis of brain activity data to create a more comprehensive picture of brain function during seizures.
Why it matters
Potential benefit: If successful, this research could lead to better surgical outcomes for epilepsy patients, potentially reducing the frequency of seizures and improving quality of life.
How similar studies have gone: Previous research has shown promise in using computational models to understand brain networks in epilepsy, indicating that this approach could lead to significant advancements.
Where this research is happening
-
The Trustees of the Stevens Institute of Technology
Hoboken, United States Active
Researchers
- Principal investigator: Liu, Feng — The Trustees of the Stevens Institute of Technology
- Study coordinator: Liu, Feng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.