Modeling Alzheimer's Disease using advanced imaging techniques
Official title: Image-based cerebrovascular network snythesis(iCNS) to model Alzheimer's Disease
Funded at University of Illinois at Chicago · NIH-11046594 · Data updated 2026-11-12
This study is working on a new way to understand how blood flow and energy use in the brain change with age and Alzheimer's Disease, using advanced MRI technology, to help find ways to slow down or even reverse these changes for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $626,654 |
| NIH project number | 5R01AG079894-03 |
| Project ID | NIH-11046594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive decline or those at risk for Alzheimer's Disease.
✕Less likely to help
Patients with early-stage Alzheimer's Disease or those with other forms of dementia may not benefit directly from this research.
What this research studies
This research aims to develop a predictive computational framework that accurately translates cerebral blood flow and metabolism data from animal models to humans, specifically focusing on Alzheimer's Disease (AD). By utilizing advanced MRI techniques, the study seeks to enhance the detection of age-related microcirculatory changes in the human brain. The goal is to quantify the physiological processes associated with aging and AD, potentially leading to methods that could slow or reverse these effects. The research will involve systematic exploration and simulation of hemodynamic and metabolic processes to identify critical aging biomarkers.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for Alzheimer's Disease, enhancing patient outcomes.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Linninger, Andreas a — University of Illinois at Chicago
- Study coordinator: Linninger, Andreas a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.